Five randomized, placebo-controlled studies of over 700 patients1,2 demonstrated that a combination of caraway oil and peppermint oil (primary component: l-Menthol) is highly effective in reducing the symptoms of FD. For the Coon study, click here.
In one randomized, placebo-controlled study of 96 patients with Functional Dyspepsia3, subjects were given either enteric-coated capsules containing a fixed combination of 90 mg peppermint oil and 50 mg caraway oil (one capsule twice daily for 28 days) or placebo. For the May study, click here.
On day 29, the average intensity of abdominal pain was reduced by 40% vs. baseline in the active arm and by 22% in the placebo arm (P=0.0003) vs. Placebo.
With respect to pressure, heaviness and fullness, a 43% reduction was observed in the active arm compared to a 22% reduction for subjects in the placebo arm (P=0.0005).
With respect to GCI (Global Clinical Impressions), 67% of subjects in the active arm described their improvement as very much improved/much improved vs. 21% taking placebo (P=0.00005).
All three of the above parameters were statistically significant for caraway oil/PO combination vs. placebo.
2Sun, X. et al. Treatment of functional dyspepsia with enteroplant: a double-blind placebo-controlled pilot phase II clinical trial. Neurogastro enterol motil. 2014; 26:51-76.